Yes, GPUs wear out from heavy use. Follow these suggestions to understand more clearly.

Cooling Fans

The cooling fans, which are physical moving pieces, are the most likely to fail. Fans keep your GPU cool by directing hot air away from the GPU chip so that it can continue to operate. 

Why is heat such a problem? Transistors won't work if they get too hot so the GPU card won't work. Even greater heat can harm the transistors in the card's chips. 

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Picture: newegg.com

Cooling fans become clogged with dust over time. This dust decreases their ability to flow air. Alternatively, if an internal lubricant fails, the fans may stop working. The GPU will become hotter in any circumstance.

Every GPU uses thermal throttling to protect itself from overheating. So, if your GPU is noisier than usual, use compressed air to clean the cooling fans and heat sink. 

If you can find a similar fan from a computer parts provider, you can replace a failed GPU cooling fan.

Faulty Thermal Compound

A layer of thermally conductive material helps transmit heat from the GPU chip to the heat sink. 

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Picture: cpuninja.com

Thermal paste can crack or lose its effectiveness over time. When this happens, the heat sink cannot cool the GPU. It causes the temperature to rise. High GPU temperatures cause thermal throttling. It slows down your GPU, as seen in the fan section above. 

In that case, the best solution is to replace the thermal paste yourself. Thermal paste is available from computer component retailers.

Failures in Other Components, Solder

A graphics card has dozens of other electronic components. For example, capacitors, resistors, memory chips, and so on, and the GPU chip. Heavy use or exposure to excessive heat could cause any of them to fail. Some people are more prone to failure than others. 

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Picture: hardforum.com

Over time, capacitors, in particular, are prone to failure. They're sensitive to temperature changes, and some are defective when they're first made. If you know how to troubleshoot capacitor problems, you can replace faulty capacitors.

Also, due to frequent temperature swings, the solder that links chips to your GPU card's circuit board might age and shatter over time. As a result, intensive GPU utilization may increase the likelihood of failure. Repairing faulty solder junctions is challenging but not impossible.

Failures in the GPU Chip Itself

So the question remains: can a GPU chip be overworked and eventually fail? Under extreme circumstances, the answer is yes. However, another component on the graphics card will fail much before that. 

Your graphics card's GPU chip comprises millions or billions of transistors. The performance of transistors degrades as they age. The chip will fail if enough transistors misbehave.

As a result, the question remains: can a GPU chip be overworked to failure? The answer is yes, in theory, under extreme circumstances. A component on the graphics card will almost break sooner. 

Heat is the Enemy

Finally, the temperature of a GPU card is the most important determining factor for how long it will last. The faster the card's components degrade, the hotter it gets. In addition, as the card heats up, it slows down to avoid catastrophic failure. Good cooling both extends the life of your card and improves its performance. 

If you're considering purchasing a used GPU, you should consider its history and how its previous owner treated and used it. More used cards (that work today) are more likely to fail in the long run. We can't be precise about how long a graphics card will last, but heavy use will shorten its lifespan.

These are a few definitions to help you know whether your GPUs wear out from heavy use or not. Graphics cards do not deteriorate. Don't allow your graphics card to overheat. Make sure it has the most up-to-date drivers, and it should do the job fine, if not better.